CDK4/6 inhibitors combined with endocrine therapy have become the standard first-line treatment for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer. However, resistance is almost inevitable. For patients who have progressed after CDK4/6 inhibitor therapy (post-CDK4/6i), remain suitable for endocrine therapy, and have no actionable genetic alterations, treatment options are particularly limited. Without biomarkers such as ESR1 mutations, alterations in the PI3K/AKT/mTOR (PAM) pathway, or germline BRCA1/2 mutations to guide treatment selection, these patients face substantial unmet medical needs.

CDK4/6 inhibitors combined with endocrine therapy have become the standard first-line treatment for patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer. However, resistance is almost inevitable, making the selection of subsequent treatment strategies a pressing clinical challenge. At the 2026 Annual Meeting of the Chinese Society of Clinical Oncology (CSCO), Oncology Frontier interviewed Professor Biyun Wang of Fudan University Shanghai Cancer Center. Drawing on clinical trial data for kermoxili, the world's first CDK2/4/6 inhibitor, and her own clinical experience, Professor Wang reviewed treatment strategies stratified by patient characteristics after CDK4/6 inhibitor resistance and identified patient populations who may benefit from CDK2/4/6 inhibition. The discussion aims to inform individualized treatment decisions for patients with HR+/HER2− advanced breast cancer receiving later-line therapy, helping improve survival and quality of life.

Treatment for early HER2-positive breast cancer is moving away from a “one-size-fits-all” approach toward dynamic, individualized decision-making guided by treatment response and multidimensional biomarkers. Genomic risk stratification, pathological complete response (pCR), and emerging biomarkers are reshaping strategies for treatment de-escalation and escalation in the neoadjuvant setting.

The 2026 Congress of the European Society for Medical Oncology (ESMO) is fast approaching. Yizekang (lunvenlatug vedotin, BL-B01D1/iza-bren), the world's first approved EGFR×HER3 bispecific antibody–drug conjugate (ADC), has achieved the primary endpoint in PANKU-Breast01, a randomized, controlled Phase III clinical trial in patients with HR+/HER2− advanced breast cancer whose disease progressed after endocrine therapy plus a CDK4/6 inhibitor and who had failed one to two lines of chemotherapy. The study has been selected for a Late-Breaking Abstract (LBA), one of the highest-profile presentation categories at the ESMO Congress. Oncology Frontier invited Professor Yongmei Yin of Jiangsu Province Hospital to discuss unmet clinical needs, analyze the potential clinical value of bispecific ADCs, and share her expert insights.

The phase III INTerpath-001 trial has reported positive interim results at the 2026 European Society for Medical Oncology (ESMO) Congress, opening a new chapter in cancer immunotherapy. In patients with completely resected, high-risk stage IIB–IV melanoma, the individualized neoantigen mRNA therapy intismeran autogene combined with pembrolizumab significantly improved recurrence-free survival (RFS) compared with pembrolizumab alone, reducing the risk of recurrence or death by 42% (hazard ratio [HR] 0.58; P<0.001). Distant metastasis-free survival (DMFS) showed a consistent, significant benefit (HR 0.62; P=0.002).

With the 2026 European Society for Medical Oncology (ESMO) Congress fast approaching, the phase III randomized PANKU-Breast01 study of iza-bren (BL-B01D1), the world's first approved bispecific antibody–drug conjugate (ADC), has reached its primary endpoint. The study evaluated iza-bren in patients with HR-positive/HER2-negative (HR+/HER2−) advanced breast cancer who had previously received one or two lines of chemotherapy. The findings have been selected for a late-breaking abstract (LBA) presentation at this year's ESMO Congress and are set to be unveiled globally for the first time. This milestone signals the beginning of a new era of bispecific ADC therapy for HR+/HER2− breast cancer.

Antibody–drug conjugates (ADCs) have profoundly reshaped the treatment landscape for advanced breast cancer. However, traditional single-target ADCs are vulnerable to antigen downregulation, which can lead to treatment resistance. Iza-kang (izalontamab brengitecan, BL-B01D1/iza-bren), the world's first EGFR × HER3 bispecific ADC developed independently in China, represents a new generation of ADCs.

As the world's first approved EGFR × HER3 bispecific antibody–drug conjugate (ADC), Izecom (izalontamab brengitecan, BL-B01D1/iza-bren) features a dual-target structure designed to overcome the limitations associated with low or heterogeneous expression of a single target. It has demonstrated remarkable antitumor activity across multiple tumor types. The phase III PANKU-Breast02 study, jointly led by Professor Jiong Wu and Professor Jian Zhang of Fudan University Shanghai Cancer Center, reported positive results for both primary endpoints, progression-free survival (PFS) and overall survival (OS), in a high-profile late-breaking abstract (LBA) presentation at ASCO. In recognition of its breakthrough clinical value, the study also received the 2026 Innovative Research Award at this year's CSCO Annual Meeting. These achievements indicate that the clinical value of izalontamab brengitecan in breast cancer is attracting global attention and recognition.

The 2026 Xianghu Breast Cancer Treatment Frontiers Academic Conference was held in Hangzhou from October 9 to 11, focusing on emerging concepts in breast cancer treatment, the integration of cardio-oncology into clinical practice, and the comprehensive management of antibody–drug conjugates (ADCs). During the meeting, Oncology Frontier interviewed Professor Zhanhong Chen of Zhejiang Cancer Hospital. She discussed the overall design and highlights of the cardio-oncology session, explained the growing importance of cardio-oncology in comprehensive breast cancer care, and shared insights into the evolving role of ADCs in advanced HER2-positive breast cancer, principles for treatment sequencing, and strategies for assessing and managing the cardiac safety of anti-HER2 ADCs.

The 2026 Xianghu Breast Cancer Treatment Frontiers Academic Conference recently concluded successfully in Hangzhou. Organized by the Breast Cancer Center of Zhejiang Cancer Hospital, the meeting featured multiple sessions covering basic and translational research, brain metastases from breast cancer, and cardio-oncology, among other topics. The Hangzhou session of the 2026 CSCO Breast Cancer (CSCO BC) Diagnosis and Treatment Guidelines Tour was also held concurrently. During the meeting, Oncology Frontier interviewed Professor Hai Hu of Zhejiang Cancer Hospital, Chair of the Conference, who shared his insights into the program structure and organizing philosophy, emerging directions in basic and translational research, the current state and future prospects of breast cancer brain metastasis management, and the development and operational model of the Precision Clinic at Zhejiang Cancer Hospital.