During the 2nd Peking University Urology Forum and the celebration of the 80th anniversary of the Department of Urology at Peking University First Hospital, Oncology Frontier – UroStream interviewed Prof. Weiren Huang from the Department of Urology, First Affiliated Hospital of Shenzhen University (Shenzhen Second People’s Hospital).

Chinese-developed immune checkpoint inhibitors, represented by toripalimab, are accelerating the transition of innovative therapies in urologic oncology from followers to global contributors. At the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, Chinese innovation was not only featured in oral presentations but also prominently showcased in the poster halls. Toripalimab combined with 9MW2821 demonstrated promising bladder-preservation potential after moving from advanced disease into the perioperative setting. Immunotherapy plus chemotherapy expanded a uniquely Chinese approach to bladder preservation. Meanwhile, a phase III neoadjuvant trial of toripalimab combined with axitinib in renal cell carcinoma marked the first randomized evaluation of a targeted-immunotherapy combination moving from the frontline setting into neoadjuvant treatment. In this issue, Oncology Frontier invited Professor Yijun Shen from Fudan University Shanghai Cancer Center to discuss key poster presentations and share his perspectives on the evolving landscape of immunotherapy in urologic oncology at this year's ASCO meeting.

From June 3 to 5, 2026, the Challenges in Laparoscopy, Robotics & AI 2026 (CILR-AI 2026) conference was held in Rome, Italy, bringing together leading experts from Europe, North America, Asia, and beyond.

The 2026 ASCO Annual Meeting has officially opened, bringing a wealth of landmark studies in genitourinary oncology and providing new momentum for precision treatment in urothelial carcinoma (UC). To promote standardized and precision-based management of urologic cancers in China, the Hainan Lecheng Hongyuan Medical Technology Innovation and Development Research Institute launched the “Academic Exchange Program on Precision Diagnosis and Treatment of Urologic Tumors,” bringing together leading experts to interpret the latest advances.

The 2026 American Society of Clinical Oncology (ASCO) Annual Meeting has once again brought together the latest breakthroughs in cancer research and drug development from around the world. As the largest and most influential oncology conference globally, every oral presentation represents a major advance in clinical practice and translational research.

Although radical cystectomy remains the standard treatment for muscle-invasive bladder cancer (MIBC) and high-risk non-muscle-invasive bladder cancer (NMIBC) that is unresponsive to Bacillus Calmette-Guérin (BCG) therapy, many patients are either unsuitable for or unwilling to undergo radical cystectomy because of underlying comorbidities and the potential impact on quality of life. Consequently, there is an urgent need to explore novel treatment approaches. At the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, a study conducted by the team of Professor Wang He and Professor Wenlong Zhong from Sun Yat-sen Memorial Hospital, Sun Yat-sen University, was selected for presentation. The study evaluated a bladder-preservation strategy combining disitamab vedotin-based systemic targeted immunotherapy with transurethral resection of bladder tumor (TURBT) and pelvic lymph node dissection (PLND), offering a new possibility for bladder preservation in patients with MIBC. Oncology Frontier – UroStream invited both experts to discuss the clinical value, efficacy, and future prospects of this innovative approach.

In recent years, immunotherapy-based combination regimens have transformed the treatment landscape of renal cell carcinoma (RCC) and have become standard first-line options for advanced clear cell renal cell carcinoma (ccRCC). However, therapeutic progress in non-clear cell renal cell carcinoma (nccRCC) has remained limited. At the 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, the research team led by Professor Hao Zeng, Professor Xu Hu, and Dr. Junru Chen from West China Hospital, Sichuan University, presented encouraging findings on first-line treatment with cadonilimab plus axitinib in patients with nccRCC, offering a promising new option for this underserved patient population. Oncology Frontier – UroStream invited Dr. Junru Chen to discuss the study and its implications.

ASCO 2026 has officially opened, featuring 518 major studies in genitourinary oncology, with antibody-drug conjugates (ADCs) emerging as one of the most exciting areas of progress. Among them, enfortumab vedotin (EV), a Nectin-4-targeting ADC, was the subject of 36 presentations, continuing to drive transformative changes in the treatment landscape of urothelial carcinoma (UC).

The combination of immune checkpoint inhibitors and antibody-drug conjugates (ADCs) is rapidly expanding from the first-line treatment of advanced disease into the perioperative setting, fundamentally reshaping the treatment landscape of urothelial carcinoma (UC). As global research momentum continues to accelerate, Chinese-developed immunotherapy–ADC combinations are emerging as important contributors to this evolving field.