Strategy for Intensification: Efficacy and Safety of BCG Plus ICI in BCG-Naive High-Risk NMIBC Based on 2,590 Patients

Strategy for Intensification: Efficacy and Safety of BCG Plus ICI in BCG-Naive High-Risk NMIBC Based on 2,590 Patients

During the 2026 European Association of Urology (EAU) Congress, Prof. Saad M.A. from the Department of Medical Oncology at the Mohammed V Military Teaching Hospital, Rabat, Morocco, presented a systematic review and reconstructed Individual Patient Data (IPD) meta-analysis. The study evaluated the clinical value of Bacillus Calmette-Guérin (BCG) combined with Immune Checkpoint Inhibitors (ICIs) in BCG-naive patients with high-risk Non-Muscle-Invasive Bladder Cancer (NMIBC).
Shifting Paradigms in MIBC Diagnosis: How Multimodal Imaging Staging Optimizes Clinical Decision-Making 

Shifting Paradigms in MIBC Diagnosis: How Multimodal Imaging Staging Optimizes Clinical Decision-Making 

During the recent academic session, Professor Antoine Van Der Heijden from Radboud University Medical Center (Nijmegen, NL) shared comprehensive insights into the management of Muscle-Invasive Bladder Cancer (MIBC). The presentation focused on the clinical significance of histological subtypes, the inherent limitations of traditional Transurethral Resection of Bladder Tumor (TURBT), and the emerging value of MRI and Vi-RADS scoring in precision staging.
80% CR Rate! SIM0237 Demonstrates Potent Anti-tumor Activity and Favorable Tolerability in BCG-unresponsive High-risk NMIBC

80% CR Rate! SIM0237 Demonstrates Potent Anti-tumor Activity and Favorable Tolerability in BCG-unresponsive High-risk NMIBC

During a recent academic session, Professor Dingwei Ye (Prof. Dingwei Ye) from Fudan University Shanghai Cancer Center provided an in-depth interpretation of the Phase 1/2 clinical study data for SIM0237—an anti-PD-L1/IL-15 variant fusion protein—specifically in patients with Bacillus Calmette-Guérin (BCG)-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC).
52.8% ORR and 87.3% 9-Month PFS Rate: Fruquintinib plus Serplulimab Shows Remarkable Promise in 1st-Line nccRCC 

52.8% ORR and 87.3% 9-Month PFS Rate: Fruquintinib plus Serplulimab Shows Remarkable Promise in 1st-Line nccRCC 

During the recent ASCO GU 2025 (Genitourinary Cancers Symposium), Professor Jiwei Huang from Renji Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine (on behalf of the research team led by Ding Yingjie), presented the updated efficacy and safety data from a multicenter, single-arm, Phase II trial. The study evaluates the combination of Fruquintinib and Serplulimab as a first-line (1st-line) treatment for patients with metastatic or unresectable non-clear cell renal cell carcinoma (nccRCC).
A Predictive Model for BCG-Unresponsiveness and Progression Based on Five Clinical Factors: A Study of 2,211 Patients 

A Predictive Model for BCG-Unresponsiveness and Progression Based on Five Clinical Factors: A Study of 2,211 Patients 

During a recent session on urological oncology, Professor A. Ślusarczyk from the Department of General, Oncological, and Functional Urology at the Medical University of Warsaw, Poland, presented the results of an international multicenter retrospective study. The study aimed to develop and validate a clinical predictive model to identify patients with high-grade non-muscle-invasive bladder cancer (NMIBC) who are at risk of BCG-unresponsiveness or disease progression following treatment.
Real-World Insights into the Safety of First-Line mRCC Combinations: ARON-1 Study Suggests Severe AEs May Predict Superior Survival Benefits 

Real-World Insights into the Safety of First-Line mRCC Combinations: ARON-1 Study Suggests Severe AEs May Predict Superior Survival Benefits 

Dr. Biagio Antonio Maiorano from the Department of Medical Oncology, IRCCS San Raffaele Hospital (Milan, Italy), presented a sub-analysis of the ARON-1 study. This analysis evaluated the real-world incidence of grade 3–4 adverse events (AEs) and their clinical impact on overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) receiving first-line immune checkpoint inhibitor (IO)-based combination therapies.
36% Reduction in DFS Risk: POTOMAC Study Validates Immuno-Combination Therapy for Elderly Patients with High-Risk NMIBC 

36% Reduction in DFS Risk: POTOMAC Study Validates Immuno-Combination Therapy for Elderly Patients with High-Risk NMIBC 

At a recent academic symposium, Professor Joan Palou from the Department of Urology, Universitat Autònoma de Barcelona, Spain, presented the latest subgroup analysis from the POTOMAC study. The presentation focused on the efficacy and safety of one year of durvalumab (D) in combination with Bacillus Calmette-Guérin (BCG) induction and maintenance therapy for BCG-naïve, high-risk non-muscle-invasive bladder cancer (NMIBC) patients aged ≥65 years.
A Predictive Model for BCG-Unresponsiveness and Progression Based on Five Clinical Factors: A Study of 2,211 Patients

A Predictive Model for BCG-Unresponsiveness and Progression Based on Five Clinical Factors: A Study of 2,211 Patients

During a recent session on urological oncology, Professor A. Ślusarczyk from the Department of General, Oncological, and Functional Urology at the Medical University of Warsaw, Poland, presented the results of an international multicenter retrospective study. The study aimed to develop and validate a clinical predictive model to identify patients with high-grade non-muscle-invasive bladder cancer (NMIBC) who are at risk of BCG-unresponsiveness or disease progression following treatment.
Optimizing mRCC Therapy: Morning Infusion of Immune Checkpoint Inhibitors Associated with a 38% Reduction in Mortality Risk

Optimizing mRCC Therapy: Morning Infusion of Immune Checkpoint Inhibitors Associated with a 38% Reduction in Mortality Risk

At a recent international uro-oncology symposium, Dr. Takemura K. from the Department of Genitourinary Oncology at the Japanese Foundation for Cancer Research (JFCR), Ariake Hospital, presented findings from a multicenter retrospective study investigating the correlation between the time-of-day administration (ToDA) of first-line immune checkpoint inhibitors (ICIs) and overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC).
Toward a “Chemo-Free” Future: Exploring Disitamab Vedotin plus Tislelizumab in the Adjuvant Setting for UTUC

Toward a “Chemo-Free” Future: Exploring Disitamab Vedotin plus Tislelizumab in the Adjuvant Setting for UTUC

During the recent academic conference, Professor Liangyou Gu from the People's Liberation Army General Hospital (PLAGH) presented the latest findings from a prospective, controlled, phase II study. The study evaluated the efficacy and safety of Disitamab Vedotin (DV/RC48), a HER2-targeted antibody-drug conjugate (ADC), combined with Tislelizumab (a PD-1 inhibitor) as adjuvant therapy for patients with HER2-expressing upper tract urothelial carcinoma (UTUC) following radical surgery.