
TP53-abnormal B-ALL is widely recognized as one of the highest-risk and most refractory subtypes of B-ALL. Not only is it highly resistant to conventional chemotherapy, but it is also particularly prone to antigen escape and early relapse following immunotherapy, posing major challenges in clinical management. During the 2026 Cross-Strait Hematology Academic Conference, Oncology Frontier – Hematology Frontier invited Professor Xiaowen Tang from the First Affiliated Hospital of Soochow University to provide a systematic interpretation of the tumor biological characteristics and high-risk factors of TP53-abnormal B-ALL. Professor Tang also discussed strategies for optimizing CAR-T therapy through lymphodepletion regimen optimization and multi-target design, as well as the comprehensive management pathway involving bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT), and looked ahead to future breakthroughs in precision risk stratification, relapse prediction, and integrated treatment.TP53-abnormal B-ALL is widely recognized as one of the highest-risk and most refractory subtypes of B-ALL. Not only is it highly resistant to conventional chemotherapy, but it is also particularly prone to antigen escape and early relapse following immunotherapy, posing major challenges in clinical management. During the 2026 Cross-Strait Hematology Academic Conference, Oncology Frontier – Hematology Frontier invited Professor Xiaowen Tang from the First Affiliated Hospital of Soochow University to provide a systematic interpretation of the tumor biological characteristics and high-risk factors of TP53-abnormal B-ALL. Professor Tang also discussed strategies for optimizing CAR-T therapy through lymphodepletion regimen optimization and multi-target design, as well as the comprehensive management pathway involving bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT), and looked ahead to future breakthroughs in precision risk stratification, relapse prediction, and integrated treatment.